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Supplemental CAT is shown to alleviate OxS in the GI tract and improve gut microbiota 576

Oligofructose promotes satiety in healthy human: a pilot study

doi: 10.1146/annurev-cellbio-020520-111016 219 DengBZhangLLiuYZhouMHeJ

Lead series optimization Our goal was to enhance interactions of the small-molecule agonists with the GLP-1R through lowering the energy barrier to achieve the receptor-bound agonist conformation, and by adjusting polar substituents, with minimal increases in molecular weight

260,261,262,263,264 This cascade of events leads to enhanced transcription of innate cytokines in various cell types including vascular endothelial cells, smooth muscle cells, and adipocytes