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At the highest doses, retatrutide seems to promise more significant weight loss than existing GLP-1s on the market but as dosage increases, so does the risk of side effects, mostly mild-to-moderate gastrointestinal issues, although one case of pancreatitis occurred in a patient on the 12mg dose during the phase II trial

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Moreover, most of the tandem duplicated genes were clustered closely, such as CmGSTU2/3, CmGSTU21/22, CmGSTF1/2, CmGSTL1/2, which confirmed the reliability of phylogenetic tree and synteny analysis

Current Pharmaceutical Design, 16(10), 12241234

proceedings of the national academy of sciences