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Cyanoenone triterpenoids This class of synthetic pentacyclic triterpenoids derives from the natural compound oleanolic acid [268, 275] , primarily reacts with C151 in KEAP1 by interrupting KEAP1-CUL3 interaction [123], and includes the strongest NRF2 activators currently known [276]
Its expected to end in 2028
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Mihalas BP, Marston AL, Wu LE, Gilchrist RB
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