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3.3 The role of Spirulina in cardiovascular diseases Cardiovascular diseases (CVDs) are leading causes of morbidity and mortality worldwide, representing a significant public health and economic burden (71)

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Substantial evidence has demonstrated that apoptosis, pyroptosis, ferroptosis, and autophagy form an intricate regulatory network, collectively determining the progression of tubular injury through shared signaling pathways and phenotype transition (200, 225, 226) ( Figure 2 )

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Mitochondrial dysfunction caused by SIRT3 inhibition drives proinflammatory macrophage polarization in obesity

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Fontana L, Klein S, Holloszy JO, Premachandra BN

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Presented for research literature review only Li JM et al

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