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IV administration also introduces risks that oral supplementation does not: Contamination or excessive endotoxin exposure Sterility and compounding failures Infusion reactions Venous irritation or infection Dosing errors Additional cost and clinical complexity The FDA has reported adverse events among patients who received injectable compounded glutathione made with an unsuitable dietary ingredient
Each puncture introduces a contamination event, and benzyl alcohol inhibits growth of introduced organisms but cannot sterilize the solution if contamination has already occurred
They can be dangerous if used for too long or incorrectly
[27] In another study, glutathione administered at a single dose of 50 mg/kg body weight led to a considerable increase of protein-bound glutathione levels in plasma but not of the deproteinized fraction, measured after two hours of supplementation
These are two different timelines
