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Morning grogginess: most research write-ups describe shifting the dose earlier in the evening before lowering the dose itself
GOAL: To educate pharmacists about currently available data on the efficacy and tolerability of the oral GLP-1 receptor agonist semaglutide in patients with type 2 diabetes
Several investigations showed that treatment with GLPs may lead to improvement in dextran sulfate sodium (DSS)- and 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis (Table 1)
Faivre, A
In contrast, while the dose-response relationship between -cell responsiveness to glucose (expressed as the slope of the linear relation between insulin secretion rate and the glucose concentration) and GLP-1 levels in circulation is partially impaired a phenomenon referred as GLP-1 resistance (62) a therapeutic infusion of GLP-1 at a pharmacological dose can restore -cell insulin secretion responsiveness to glucose levels comparable to those observed in nondiabetic individuals (62)
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