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It was first isolated from human plasma, where it naturally occurs at concentrations of around 200 ng/mL at age 20, declining to approximately 80 ng/mL by age 60
249 Nuclear STAT3-Y705 activates glycolysis and fatty acid oxidation (FAO) genes, while mitochondrial STAT3-S727 and acetylated STAT3-K685 impair oxidative phosphorylation by destabilizing electron transport chain (ETC) complexes, supporting leukemia stem cell dormancy and persistence
This ordered shuttle system ensures the normal concentration and metabolic balance of carnitine within the cell [184, 185]
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Yeung, F
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