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This setting may allow earlier insights into treatment effects, particularly via DNA-methylation based epigenetic clocks and other emerging aging biomarkers, which are recently being considered as outcome measures in double-blind, randomized geroscience trials 17 and global competitions testing gerotherapeutics 18

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Neuroprotective effects of the novel GLP-1 long acting analogue semaglutide in the MPTP Parkinson's disease mouse model