The model was refined against one half map, and FSC curves were calculated between this model and the final cryo-EM map (full dataset, blue) of the outcome of model refinement with a half map versus the same map (orange), and of the outcome of model refinement with a half map versus the other half map (green)
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In 2025, Wegovy was given additional FDA approval for treating a liver disease known as metabolic dysfunction-associated steatohepatitis (MASH), which causes inflammation, scarring, and fat deposits in the liver
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Due to differences in mechanisms, dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonists were not included in the definition of GLP-1 RAs users in this study [35,36,37]