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A recent study demonstrated that hyperglycemia in erythrocytes of patients with type 1 diabetes mellitus (T1DM) is associated with an increased percentage of circulating erythrocytes that expose PS at the cell surface
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The loss-of-function interventions (for example, pharmacological AMPK inhibitor and Pgc-1 knockdown) completely abrogated the transcription of mitochondrial genes in response to energetic stress (106)
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However, some individuals, including pre-term infants, cannot make enough and L-carnitine must be supplied in the diet
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