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DPP-4 is responsible for the inactivation of GLP-1 by cleaving two N-terminal amino acids proline or alanine from natural peptides in the penultimate (P1) position

"So they end up just injecting themselves with random stuff, and sometimes, it goes wrong

A new study found that a new type of medication , called eloralintide, which targets a different hormone called amylin, helped people achieve meaningful weight loss

The randomised, double-blind, placebo-controlled trial enrolled adults with type 2 diabetes managed with diet and exercise alone or with stable oral antidiabetic therapy (excluding sulphonylureas and insulin in most arms)

Standard GLP-1 receptor agonists reduce liver fat, but the effect is driven primarily by caloric restriction and weight loss rather than direct hepatic receptor activity