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In some cases, like acetaminophen overdose, the mechanism is well established
Unlike other VE compounds, T3-13'COOH, a natural metabolite of VE, has been shown to specifically activate (pregnane X receptor) PXR without being influenced by the pharmacological inhibition of PPAR activity [126]
To test our hypothesis, we first detected GCLC expression and found that when NRF2 was knocked down, the inhibition of GCLC expression by ACTL6A KD was diminished
This routes the nutrient directly into the bloodstream without an intermediary tissue depot
Therefore, both excessive activation and inhibition of Nrf2 may be detrimental to DOX-induced cardiomyopathy
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