Cystic fibrosis is characterized by Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) dysfunction in the airway epithelium, leading to impaired mucociliary clearance and defective innate immune responses which promote chronic bacterial colonization
GLP-1s are no longer just promising metabolic drugs
These weight loss drugs have shown promising results, especially for those struggling with obesity
However, human, but not rodent, cytotoxic granules contain the antimicrobial peptide granulysin (GNLY), which selectively destroys cholesterol-poor microbial membranes 11,12,13,14 , and GNLY, PFN and Gzms rapidly kill intracellular bacteria 15
Many insurances, including UnitedHealthcare, Cigna, Blue Cross Blue Shield, Aetna, Medicare Part D, and Medicaid, may cover these medications when prescribed appropriately