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Nef promotes neuropathology by upregulating CCL2 in microglia and enhancing IL-6 and IL-8 production in astrocytes [137,138,139], while also activating NADPH oxidase in phagocytes, thereby exacerbating neuroinflammation, myelin damage, and neuronal injury [134, 140]

GHK-Cu vs AHK-Cu: Which Copper Peptide

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Danish drugmaker Xellia Pharmaceuticals also referenced the ICH Q3A and Q3B guidelines, which it said exclude peptide, fermentation, and semi-synthetic products, leading to a knowledge gap in how impurity limits should be established for the antibiotics referenced in FDA's guidance