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Key changes that can occur after stopping include: Blood Sugar Control: For those with type 2 diabetes, stopping a GLP-1 agonist may lead to worsening glycemic control, requiring alternative medications or insulin therapy

References Lopaschuk GD, Karwi QG, Tian R, Wende AR, Abel ED

The 2024 semaglutide phase 2 RCT and the Weill Cornell cohort data are the most rigorous current evidence showing bone loss - but reasonable endocrinologists interpret even those findings with appropriate uncertainty about generalizability

The tirzepatide hydroxocobalamin variant represents a third option with its own absorption characteristics

Most people notice subtle changes rather than dramatic ones