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When carbohydrate intake is substantially reduced or when the body is in a significant caloric deficit, the liver begins breaking down fatty acids into ketone bodies (acetoacetate, beta-hydroxybutyrate, and acetone) to provide an alternative fuel source for the brain and other tissues
In the Phase 3 REDEFINE 1 trial, CagriSema produced a mean body weight reduction of approximately 22.7% from baseline at 68 weeks in adults with obesity (without type 2 diabetes)
Lifestyle: Factors like diet, exercise, sleep, and stress all play a role
Microdosing, by contrast, involves maintaining doses below these established starting points or progressing more slowly than recommended
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