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76 GLP-1 receptor agonists improve IR by reducing body weight in PCOS patients [31]

Ozempic works by mimicking a hormone naturally found in your body

Fatigue and insomnia can occur, sometimes paradoxically at the same dose level

The high cost of GLP-1 medications, averaging USD 1,200 per month, limits access for many patients

Numerous studies have demonstrated the therapeutic potential of phytomolecules in preclinical cellular and animal PD models, with their ability to exert pleiotropic neuroprotective effects by targeting, inflammatory signaling, mitochondrial dysfunction, S aggregation, and key pathways including sirtuins and PI3K/Akt signaling ( Future research should also aim to disentangle the mechanistic interplay between S accumulation, sirtuin dysregulation, and impaired insulin signaling in PD, to identify which phytomolecules are most effective in counteracting mitochondrial stress, mitophagy defects, and neuronal apoptosis