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However, a systematic review in 2023 found only one phase 2 randomized controlled trial of exenatide versus placebo for IIH, which did demonstrate a significant reduction in ICP at all time points, as well as improved headache and visual acuity (7,8)
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Some of the findings include the following: In a 2022 trial, subjects taking 1,000mg of urolithin A exhibited clinically meaningful improvements in their aerobic endurance and physical performance when compared to subjects who took either 500mg or a placebo.5 A separate 2022 trial examined the effects of 1,000mg urolithin A versus placebo in older adults after four months of daily supplementation
a GLP-1R expression detected by transgene expression in mice [65], density of GLP-1R-immunoreactive fibers in each brain region determined by rat immunocytochemistry [66], GLP-1R expression determined by ISH in non-human primates [67]
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