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5-Amino-1MQ Key Research Facts Chemical name: 5-Amino-1-Methylquinolinium (also abbreviated as 5A-1MQ or 5MQ) Target enzyme: Nicotinamide N-Methyltransferase (NNMT) Mechanism: Competitive inhibition of NNMT reduces 1-MNA production, preserves nicotinamide for NAD+ synthesis and SAM for epigenetic methylation Selectivity: High selectivity for NNMT does not inhibit related SAM-dependent methyltransferases or NAD+ salvage pathway enzymes Membrane permeability: High passive and active transport permeability confirmed in PAMPA and Caco-2 cell assays NNMT expression: Upregulated in obese adipose tissue, multiple cancer types, and aged skeletal muscle tissue contexts of primary research interest Downstream targets: NAD+ availability, SIRT1/SIRT3 activity, SAM-dependent epigenetic methylation, lipogenesis, energy expenditure Pre-clinical models: Diet-induced obese (DIO) mice, 3T3-L1 adipocyte cell models, aged mouse skeletal muscle models, HeLa cancer cell lines In vitro cell viability: No impact on cell viability at 10 M concentration in 3T3-L1 pre-adipocytes in published toxicity profiling What Does 5-Amino-1MQ Do in Research
[1] Those who cannot digest or absorb B12 as a result of inherited genetics or damage to the stomach and small intestine require more than can be absorbed from sublingual supplementation
Ensuring a Sterile Environment Maintaining a sterile environment is paramount to prevent contamination and ensure the efficacy of the Semaglutide
5-Amino-1MQ 50mg x 25ct $120.00 Volume discounts Auto-applied at checkout Free shipping on orders of $200+ Compound Identity COMPOUND NAME 5-Amino-1-MQ SYNONYMS 5-amino-1-methylquinolinium, 5MQ CAS NUMBER 685079-15-6 MOLECULAR FORMULA C 10 H 11 N 2 + MOLECULAR WEIGHT ~159.21 g/mol STRUCTURE Quinoline core with a methyl group at the 1-position and an amino group at the 5-position 4
Refrigerator-compatible storage keeps bottles cool, helping to maintain the stability and effectiveness of medications and ensuring safe and reliable use
