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For time to pregnancy, hazard ratios remained below 1.0 in all groups0.60 (95% CI 0.271.32) for overweight, 0.75 (95% CI 0.501.12) for class I obesity, and 0.91 (95% CI 0.651.29) for class IIIII obesitywith corresponding log-rank tests nonsignificant
Transitioning off the combination How you end the combination protocol matters as much as how you start it
Both medications produce substantial, clinically significant results that dramatically exceed traditional weight loss methods
California, 2022)
Over time, MASH can lead to liver fibrosis, cirrhosis, and even liver failure that requires a liver transplant, making it a major public health concern
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