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The honest boundary is that even the coherent pairing is a mechanistic hypothesis with no human validation, so the most defensible research posture is to study the single compound at its documented dose first, and treat any combination as a further, clearly-labelled research question rather than a default
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[24] How soon should neurologic symptoms begin to resolve after starting therapy
[Journal of Endocrinology & Metabolism] Obesity drug codenamed AOD9604 highly successful in trials, News-Medical.net, 16-Dec-2004
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