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The effort needed to optimize these regimens can be experienced as aversive, promote frustration, and generate a desire to avoid such effort, aligning with a region of the brain called the anterior midcingulate cortex, as described by Lisa Feldman Barrett and colleagues
Some patients start with semaglutide because coverage is easier to obtain, then switch to tirzepatide if results plateau or if coverage changes
For this reason, if you have Hashimotos, you better make sure that your low thyroid symptoms are managed and controlled
I find the simplest lifestyle modification produces the best results: a consistent morning routine
Despite the fact that brands like Mounjaro and Zepbound both use tirzepatide and that Wegovy and Ozempic both use semaglutide, each brand is typically prescribed for one purpose or the other
