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Evaluation of autophagy markers in the lung tissues showed inhibition of LC3B, eosinophil main basic protein, and promotion of p62 expression [160]
A structural explanation for these findings was provided from our previous cryo-EM structures of CT(Pro32) and rAmy(Tyr37)-bound AMYRs structures where the bulky phenolic side chain of Y37 rAmy forms perpendicular stacking interactions with W79 ECD 15 , and additional interactions with the respective RAMP protomer that are likely important for selectivity of rAmy for AMYRs over CTR
Check combinations with the peptide interaction checker, review GHK-Cu benefits to weigh the upside, and see a dermatologist for any persistent, spreading, or swelling reaction
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