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The lid domain and glycine-rich loop are critical for ATP binding, which triggers major shifts in their conformations (Galant et al., In the structures of human and yeast GS, two alanine residues form van der Waals contacts with the glycine moiety of glutathione (Polekhina et al., These structure/function studies established the basis of glutathione versus homoglutathione specificity, but it remains unclear how other glutathione analogs are formed in different plants

But the same peptide compound, which is not regulated by the FDA, is also being advertised by gray-market sellers online, and thats where you can run into issues theres no guarantee of those products purity and dosage

In more extreme cases, a deficiency could contribute to neurological issues, particularly in children

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