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Description

MHRA position)

PMID 29141978

(N = 56)

As underlying mechanisms, it has been reported that GLP-1 causes renal vasodilatation, increases renal blood flow, increases glomerular filtration rate, inhibits the Na + /H + exchanger 3 in proximal tubule and decreases sodium, bicarbonate and water reabsorption [12, 14]

The case reports involved patients aged 56 and 75, but whether age is a risk factor or simply reflects the demographics of semaglutide users is unclear