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The answer should be semaglutide base

Research from the SURPASS and SURMOUNT clinical trial programs has consistently shown this dual mechanism translates into superior clinical outcomes across nearly every measured endpoint

They can recommend ways to manage these effects, such as: staying on the lower initiation dose for longer to let your body adjust taking an over-the-counter treatment for digestive problems adjusting your diet, exercise, sleep, or other lifestyle habits If even the lowest maintenance dosage of your GLP-1 medication feels too strong, your prescriber can recommend other, non-GLP-1 alternatives for your condition

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But along with its benefits, some patients notice an unexpected side effect new or worsening back pain