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Thyroid hyperplasia and nodular development can be induced by the use of rodent models and transgenic mice with mutations in genes such as Ras or TSH receptor mutations

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Primary outcomes measured the number of patients who developed an ocular adverse event, DR, or NAION

That said, these effects are not yet well established clinically, and more research is needed to determine whether they are directly caused by the medication or influenced by factors such as weight loss, metabolic changes, or individual physiology

Retatrutides GLP-1 activity reduces hunger and slows gastric emptying, making large protein-rich meals difficult to tolerate