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One of the major pharmacological barriers is the BBB, which restricts the entry of most therapeutic agents into the central nervous system
( c ) Blue-native (BN-PAGE) followed by western blot detection of indicated subunits in native complex I-III in BCS treated SEM cells (day 8) or NALM6 cells (day 6)
This change is crucial because it modifies the property of binding to blood proteins, which previously led to a very short residence time in the body
This age-related decrease correlates with reduced regenerative capacity, suggesting that exogenous administration could restore youthful tissue repair patterns
PMID 6020678
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