glp-1 physiology Mechanisms by which agonists may exert beneficial effects on the Glucagon-like peptide 1 in health

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In trials, GLP-1 medications also reduce: Non-HDL cholesterol and triglycerides Systolic blood pressure (typically 36 mmHg) High-sensitivity C-reactive protein (hsCRP), a marker of systemic inflammation by as much as 47.7% in ATTAIN-1 [2] HbA1c in patients with type 2 diabetes or prediabetes Early and emerging evidence suggests benefits in other conditions too

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More recently, a C-peptide-sparing effect of TNF- blockade was reported with golimumab use, after 1 year in children and young adults with type 1 diabetes [51]