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Patients should contact their GP or prescribing clinician if a weight loss plateau persists beyond 812 weeks despite implementing lifestyle modifications
After 3 to 4 months on tirzepatide, if its specific side effects (perhaps insomnia or different GI patterns) become problematic, returning to semaglutide allows your body to reset from tirzepatide-specific effects
This transformation began in late 2022 and accelerated through 20242025 through consistent exercise, improved nutrition, and behavioral changes
Li Z et al
It does not represent harmful drug build-up but rather optimal therapeutic dosing
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