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In the realm of targeted therapy, the intermittent use of the PI3K// inhibitor BAY1082439 (NCT01728311) was shown to reprogram the immune microenvironment and sustain antitumor responses, particularly in PTEN-deficient cancers

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This sounds revolutionary, but it has received a mixed reception among clinicians, with many citing concerns that once-monthly dosing may paradoxically worsen patient compliance (patients may simply forget to take the medication, as once-monthly administration may not be frequent enough to build adherence behaviours) and slow dose titration

A 7-day treatment with 100 nmol/l Ex-4 promoted upregulation of pro-adipogenic genes associated with both white and brown adipose tissue [16]

(35(9)):1256.e1-1256.e2 doi:10.1016/j.cjca.2019.05.014