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K58.0 (IBS with diarrhea) requires documented abdominal pain that's associated with bowel movement changes and may be relieved by defecation

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Mechanisms that commonly induce ROS generation in viral infections include the deregulation of mitochondrial function, activation and upregulation of NOX production, and modification of the Nrf2/ARE pathway, with superoxide being the most commonly produced ROS 55

In preclinical models, Dihexa demonstrated superior pharmacokinetic properties, including good oral activity and effective BBB penetration, along with enhanced metabolic stability with a half-life of 335.5 minutes