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In order to substantiate the therapeutic potential of JMF4073 for TKI-resistant T315I-Bcr-Abl cells, we investigated the mechanism responsible for the differential response to JMF4073
Accessed November 16, 2017
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These peptides activate MRGPRX2, a mast-cell receptor that fires on positively charged, aromatic molecules and releases histamine into the tissue. Sodium and chloride ions screen the peptides positive charge, so the receptor sees less of it and the welt shrinks
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