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By directly downregulating SIRT1, miR-34a leads to increased synthesis of inflammatory cytokines, including IL-6, TNF-, IL-1, and IL 8, and oxidative stress proteins, including MCP-1, vascular cell adhesion protein 1 (VCAM1), and MDA, and decreased levels of the anti-inflammatory cytokine IL-10 [297, 303]
As a result, it can stop users from over-eating
Cycle: 5 days per week for 1-3 months, followed by 2-4 weeks off
Epidemiol Health
Fizzy drinks + big portions are often to blame
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