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Eligibility typically requires a BMI 35 kg/m (or 32.5 kg/m in people from certain ethnic groups), or a BMI 30 kg/m with weight-related comorbidities, alongside engagement with lifestyle modification programmes
In clinical trials, participants receive structured support, regular monitoring, and often nutritional counseling
The appetite-suppressing properties of both medications can theoretically amplify each other, creating a combined reduction in food intake that exceeds what either drug produces alone
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