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Mediators Inflammation (2019) 2019:2923072
Exposure of healthy organs to medication is unnecessary and most often will lead to side or toxic effects which are especially an issue for medication with a narrow therapeutic index
While the molecular ruthenium catalyst and the nanoreactors without carbon fluorinated moieties were cytotoxic in the low micromolar range in a 21% O 2 atmosphere, these compounds lost their therapeutic effect in a 1% O 2 atmosphere
Metformin lowers Ser-129 phosphorylated -synuclein levels via mTOR-dependent protein phosphatase 2A activation
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