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YAP/TAZ upregulates key Hedgehog genes (e.g., Gli1), while activated Hh signaling promotes YAP/TAZ nuclear localization and activates p38 MAPK via non-canonical pathways
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With respect to targeted therapeutic strategies, the focus on key transporters and metabolizing enzymes (ASCT2/GLS1) provides a theoretical foundation for the development of multi-targeted combination therapeutic regimens based on the inhibition of glutamine metabolism
El hgado se encarga de filtrar las toxinas, los metales pesados, el alcohol y los medicamentos del torrente sanguneo, y el glutatin acta como un escudo que se une a estas sustancias nocivas y facilita su eliminacin
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