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In vitro drug release studies in simulated intestinal fluid (SIF) and gastric fluids (SGF) revealed that over 80% of the two drugs were released within 5 h in SGF, with a sustained release observed up to 24 h in SIF

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Using the CMap database, we found that cinchonine presented the highest score indicating that this compound exerts GLP-1R agonist-like effects

It is interesting to speculate that the increase in COX activity may underlie anxiety, as demonstrated in K2