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The neutral trimetazidine has very low solubility in an aqueous solution while its dihydrochloride salt form is water soluble [113]
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ATP-dependent helicases such as DHX9, the Blooms syndrome helicase (BLM), Aquarius (AQR), FANCM and members of the DExD/H family of RNA helicases or chromatin regulatory factors such as the FACT and SWI/SNF chromatin remodeling complex, INO80 and DAXX/ATRX histone chaperons prevent unprogrammed R-loops 4,10,11,12,13,14
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