glp-1 drugs retatrutide Use of an unapproved triple-hormone receptor agonist bought online led to extreme side effects stemming from intractable diarrhea in a man who obtained the drug online from a direct-to-customer seller. The patient Retatrutide for Weight Loss: TRIUMPH-1

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In the REDEFINE 1 phase 3 trial (NCT05567796), which enrolled adults with overweight or obesity (BMI 27 kg/m) and at least 1 weight-related comorbidity but without type 2 diabetes, participants receiving CagriSema (cagrilintide 2.4 mg + semaglutide 2.4 mg) achieved a mean body weight reduction of 22.7% from baseline after 68 weeks among adherent participants, compared with approximately 3% in the placebo group.5 These results establish CagriSema as one of the most potent antiobesity therapies investigated to date

Adler V, Yin Z, Fuchs SY, Benezra M, Rosario L, Tew KD et al

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