.25 glp 1 GLP-1 medications work. But up to 25% of the weight lost is muscle unless you actively protect it. Two things change everything: Protein. Strength training. Simple. Evidence-based. Essential. Full… With FDA approval of Wegovy

And literally, Eric, the smartest thing that we did, and we didn't expect this, it's always the law of unintended consequences

expounded on the obesity paradox, suggesting increased BMD is offset by poor bone quality due to advanced glycation end-products (AGEs) accumulation, impaired osteoblast function, and uncoupled bone turnover favoring resorption

A.VankyE.et al (2018)

However, in resistant patients, oxidative stress causes a conformational change in Keap1, leading to the release of NRF2, which translocates to the nucleus and binds to antioxidant response element (ARE), activating the expression of downstream antioxidant genes, including GPX4, NQO1, HO-1 and SOD1 [33], and promoting the synthesis of GSH, as illustrated in Fig

Greger V, Schirmacher P, Bohl J, Bornemann A, Hrter T, Passarge E, et al