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Very high doses over prolonged periods may increase the risk of toxicity or metabolic imbalance.Seek medical attention if overdose is suspected

Methodologically akin to a retrospective cohort analysis, our study differs in that it emulates a target trial by prespecifying the protocol, aligning index date, and using propensity score matching to emulate randomization, thereby reducing immortal-time bias, improving transparency, and aligning real-world evidence generation with clinical trial standards

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The increase in potential exposure in recent years is apparent from our study, in which, among a broader cohort of more than 2.1 million pregnancies, the prevalence of GLP-1 dispensing in the 90 days prior to the last menstrual period and conception increased from 2 per 1,000 in 2020 to 15 per 1,000 in 2024, Brown explained