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While the known risks of weight loss drugs are generally minor to moderate, patients are also at a higher risk of developing certain endocrine tumors in the pancreas or thyroid glands, as well as pancreatitis and possibly cancer

Simple strategies such as adjusting eating habits, staying hydrated, and slowing dose increases can help manage symptoms

When metformin is taken with carbonic anhydrase inhibitors, it can increase the risk of a dangerous condition called lactic acidosis

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Both Mounjaro's prescribing info and retatrutide trial design reflect the idea of starting lower and stepping up to reduce side effects