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The Metsera acquisition suggests Pfizer believes metabolic disease is a priority area to become a top-tier business we should watch Pfizers pipeline for new obesity/metabolism projects (possibly built via smaller partnerships)
Although findings from clinical studies are promising, there are concerns that long-term exposure of GLP-1 RAs at supratherapeutic or maximum approved maintenance doses may impair muscle cell differentiation and potentially contribute to the development of sarcopenia, despite their potential to improve muscle metabolism and quality [83, 88]
Therefore, GLP-1R agonists are promising agents for the treatment of obese individuals
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