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Another form of renal toxicity, generally associated with NSAIDs, is seen in patients with prerenal conditions leading to the reduction in renal blood flow or blood volume, where the renal prostaglandins have a supportive role in maintaining renal perfusion

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External Heres the simplest way to understand it: They are solving different problems

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Phase 2: 0.50mg weekly (weeks 5 to 8) This is where most researchers start feeling the medication work