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While the exact mechanisms leading to NASH are still unclear, the prevalence of obese patients diagnosed with NASH strongly suggests lack of blood sugar control, insulin resistance, and blood lipid problems may play a significant role (2)
The four-pathway model therefore targets appetite (GLP-1 and amylin through separate neuronal circuits), fat metabolism (GIP and glucagon), energy expenditure (glucagon primarily), and glucose homeostasis (GLP-1, GIP, and amylin all contribute through different mechanisms)
10002000 g daily) can correct deficiency in some cases (even without intrinsic factor, because a small fraction can be absorbed passively)
Common drugs used include alprostadil, papaverine, and phentolamine, either alone or in combination
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