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In 1973 he was trying to figure out why blood plasma from older donors behaved so differently from younger plasma when both were dripped onto the same liver cells in culture
The reaction reflects regenerative signalling and barrier disruption during the adjustment period, not permanent harm
doi:10.1016/s0092-8674(00)81271-4
Enhanced angiogenesis could speed this compensatory process
Konopleva MY, Hu WX, Lu Y, Carter BZ, Mills GB, Andreeff M
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