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This condition mimics true hypoxia by increasing the intracellular reduced and oxidized nicotinamide adenine dinucleotide (NADH/NAD) ratio, thereby disrupting cellular redox homeostasis
As the tumor grows, stimuli in the TME alter, resulting in changes in TAM infiltration and polarization in a tumor progression level-dependent manner
However, their use is not without adverse effects, particularly gastrointestinal disturbances, which can impact treatment adherence and patient satisfaction [6]
The shortages are primarily due to high demand for these drugs for weight loss and diabetes management, which outpaces the supply
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