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Findings from the SELECT trial , published in 2023, revealed that semaglutide reduced the risk of heart attack and stroke by 20% in people with pre-existing cardiovascular disease
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2015 examined obese male mice on a high-fat diet and reported that while the HFD mice had lower serum testosterone (which exenatide treatment did not fully restore), the GLP-1 RAtreated mice did show improved sperm motility, enhanced sperm mitochondrial activity, and reduced sperm DNA fragmentation compared to untreated obese controls
Most GLP-1 users need 2,000-3,000mg sodium daily (combined from electrolytes and food) to offset increased urinary excretion and reduced intake from appetite suppression
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