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Amgen's MariTide, which combines GLP-1 agonism with GIP antagonism, was specifically designed based on genetic evidence suggesting this combination could reduce nausea while maintaining weight loss efficacy [44]

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Additional information on risks and uncertainties can be found in the Companys Annual Report on Form 20-F, as amended, for the year ended April 30, 2024 (available on the Companys SEDAR+ profile at www.sedarplus.ca and EDGAR profile at www.sec.gov/edgar)

Pickett CG, Lu AYH 1989 Glutathione-S-transferases: gene structure, regulation, and biological function

The concern is that if you overstimulate melanocytes, particularly in someone who has an underlying tendency to skin cancer, you could increase the risk of melanoma developing. In addition, melanotan II often goes along with other risky sun-seeking behaviour such as sunbed usage, Dr Wedgeworth says